Manual patch clamping requires considerable skill and experience due to the technically challenging setup requirements, and as such, only allows recording of a small sample of cells (approximately ...

To record ion channel activity across cell membranes the conventional patch clamp remains the gold standard and is widely used in drug discovery research. However, this traditional method requires ...

Despite the importance of the mammalian neocortex for complex cognitive processes, we still lack a comprehensive description of its cellular components. To improve the classification of neuronal cell ...

Flip-the-Tip Technology Uses Standard Glass Pipettes to Achieve Higher Throughput in Ion Channel Screening The pharmaceutical industry has widely recognized patch clamping as the “gold standard” to ...

High-throughput screening (HTS) is a drug discovery strategy used extensively during early-stage pharmaceutical development. The patch-clamp technique remains the gold standard for testing the ...