Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...

The DNA in our cells is susceptible to a barrage of agents that can cause damage, including radiation or toxic substances such as alcohol. Researchers of the Hubrecht Institute (KNAW) in Utrecht, the ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...

The human genome is contained within the nucleus of cells. The genome is well protected, but many things can cause DNA damage, including aging, some drugs, and environmental factors like UV rays or ...

How an enzyme involved in DNA repair becomes vital to the survival of certain cancers has been identified by scientists, paving the way for clinical trials evaluating the effects of blocking this ...

Better understanding of the mechanisms involved in DNA repair may pave the way for developing inhibitors to improve the effectiveness of radiation therapy. Nucleotide excision repair (NER) is a ...

Homologous recombination is a DNA repair mechanism that counteracts double-stranded breaks in DNA. Researchers at Kindai University have recently revealed how the Sae2 protein coordinates with the ...

Scientists at the University of Birmingham and the Francis Crick Institute have discovered a new way in which cancer cells repair double-stranded breaks in DNA. The findings were published in a paper ...

Researchers at Washington University School of Medicine in St. Louis have shed new light on a process that fixes breaks in the genetic material of the body's cells. Their findings could lead to ways ...

Deoxyribonucleic acid (DNA), is the macromolecule that holds all hereditary and genetic information. Continuously under assault, alterations and damage to DNA can lead to many different health issues, ...

A research team has unveiled a crucial mechanism that helps regulate DNA damage repair, with important implications for improving cancer treatment outcomes. The result was published in Cell Death & ...

Prime editing is an improved variant of the CRISPR/Cas system that can introduce alterations in DNA with exquisite precision. But the method is complex and inefficient. A research group has now been ...